Wednesday, December 3, 2008

IVF 11: They're in my uterus, stealing my eggs.

In one of my favorite children's books, Tal, an itinerant storyteller named Noom-Zor-Noom is trying to win a king's contest for best children's story. He asks the child Tal to accompany him as he travels to the kingdom, while Noom-Zor-Noom reads Tal his stories so that Tal can select the best.

The book is a delightful mixture of their journey, Noom-Zor-Noom's stories, and a talking donkey. I highly recommend it for children in the age 6-11ish range.

Anyhow, Tal's favorite story (spoiler!) involves a giant who overtakes a carefree tropical village. The giant demands that the villagers feed him all their best fruit, with only the unripe or damaged fruit left over for the villagers, who begin to grow weak and despairing. Finally they hatch a bold plot: they open a number of fruits, scoop out the flesh, and replace it with stones. Then they sew the fruit back up again and feed it to the greedy giant.

The giant is incapacitated by a terrible stomachache from the rocks in his belly and never bothers the villagers again.

For the last few days, I have felt increasing sympathy for the giant.

I am a thin woman; I do not have "fat" days; if my jeans are too tight it is because they have just emerged from the dryer, not because I have put on weight.

But for the last three days, I have exclusively worn a pair of corduroys that used to gap dreadfully at the waist. The 32 follicles reached 15-20 mm in diameter, and my abdomen was swollen and tender. It was sometimes painful to walk, and I stood and sat like a 7-months-preggo lady: using my arms for leverage.

Today they fished the little girls out. The anesthesia consisted of a sedative for the surgery prep, followed by the intravenous anesthetic propofol. Here's what I remember:
--changing into one of those awful hospital gowns + hair net (just like in the mouse colony!)
--Golden oldies radio station.
--The nurse-anesthetist taking three tries to find a vein.
--Demanding an extra blanket.
--"The sedative should take effect shortly, but you'll still be conscious up until the moment that they go in for the retrieval."
--"Put your legs up on these padded bars."
--Waking up in the recovery room.

Here's the funny part. I was apparently quite a chatty patient. Both nurses say that I was peppy and asking questions ("Really good questions," marveled the anesthetist) up until they gave me the actual propofol dose. I looked with interest at the ultrasound. They sterile scrubbed me inside and out. I have absolutely no memory of any of this.

Nor do I have any memory of my first hour or so of recovery, during which I apparently asked yet another barrage of questions ("So Dr Earnest Resident and Dr Big Shot each did one ovary? Who did which one?") Dr Hyde says that I was also making witty comments (Dr Hyde: "They're still counting all your eggs--they probably don't have enough capacity to count them all because you had so many!" Dr Jekyll, nuttily: "They had to add an extra bit to the computer--16's not enough.") WTF, Dr J, WTF.

Zero recall. It's like having been through an alcohol blackout, sans hangover, when you wonder what incriminating secrets or irritating propensities you might have shared.

Anyhow, they retrieved 27 eggs, of which 13 were mature (yes!!), 10 were "intermediate," meaning they'll slosh them in the incubator in hopes of ripening them up enough for insemination, 3 were too immature, and 1 was too old.

The whole procedure took longer than anticipated, in part because of my Ovarian Bounty, and in part because they dropped something into the sterile field, so they had to take off all the drapes, resterilize, rescrub, and replace everything. Again, no memory of this.

While it's great news that there are so many potential eggs, because there's a drop-off at the fertilization step (only ~60% are likely to become fertilized, even after they inject a sperm), it also suggests that I am at risk for ovarian hyperstimulation syndrome. Mild OHSS (bloating, cramping-- check, check) is not a big deal, but if it progresses, the ovaries swell up and fluid accumulates in places it shouldn't, possibly requiring hospitalization.

I am supposed to pay close attention to whether I gain more than two pounds in a single day (fluid alert). We don't even own a scale.

Perhaps I will just drape my still-tumescent belly over the balance in lab. This will cause all my labmates to think I am crazy and to stay the hell away from me, so that would be awesome really unfortunate.

Thanks for all your good wishes. We hear tomorrow how the fertilization went.

14 comments:

LindaCO said...

I apologize if you've talked about this already. Assuming things go well, will you face the decision of keeping only a certain number of embryos?

Again, hope everything goes better than expected. Thanks for sharing your experiences.

Dr. Jekyll and Mrs. Hyde said...

If all goes well, we are going to transfer two embryos (to my uterus) and freeze any remaining, so that if this round doesn't work, or if we want to add to the family later, we can thaw a couple rather than go through the ovarian stimulation again.

If we eventually decide that we have enough kids and there are still embryos in the deep-freeze, we will donate them to research if possible, discard them if not.

hgg said...

Wow, what an adventure you're going through, and hopefully only once!

chall said...

wow, it sounds like a good egg retreival! I am happy for you.

On a side note on the not remembering anything. When I woke up from my [so far only] surgery I apparently talked and yelped ;) no memory. Talking to the people in the OP prior to sleeping? Sure. Remember it? Not at chance ;)

I wish you best wishes for tomorrow!!

chall said...

oh bte, if you don't mind me asking. Will the transfer of the embryos happen instantiously? I guess that is how it's done?

I am just wondering since you had all those hormones prior to taking out the eggs, and then when you are still having some of that left you implant the embryos? Or are there other hormones involved wit that proceudre? (I am just curious, I don't mean to snoop. If the question is out of line never mind it. ok?!)

Dr. Jekyll and Mrs. Hyde said...

Transfer won't happen for another few days, during which I stop all the follicle stimulation hormones and switch over to progesterone, which in theory should help my body think it's pregnant.

Jenny F. Scientist said...

It's fascinating to hear about this process from you- and I really hope your body is successfully fooled and all.

Nat Blair said...

Wow, that was some excellent work there! Glad that the stimulation went so well.

So are you guys transferring embryos or waiting until blastocyst stage? Sounds like embryos.

Still hoping that things work out for you!

Anonymous said...

I've just been told that I have "kissing ovaries" which means that IVF is really the only option if we want to have our own kids. My husband and I have to make some hard decisions. Do you have any suggestions about websites? Also are you happy with the decision to go the IVF route - I guess I'm wondering about the expense?

Dr. Jekyll and Mrs. Hyde said...

Hi Nat, we're doing blastocysts--I've just been using the term "embryos" indiscriminately here. Monday will be the five-day transfer date...

Anon, I'm so very sorry. What are kissing ovaries? Twisted fallopian tubes?

I looked at a lot of websites. http://www.advancedfertility.com/ivf.htm has a lot of pictures and info, as does this site in Georgia http://www.ivf.com/index.php.

There are also a LOT of message boards out there that you might like to look through--just google "ivf message board" or similar. They all have slightly different styles. I have to say that I didn't like reading them for a few reasons. First, the number of people posting about how they finally got their positive result is depressing; second, the people posting about how they got yet another negative result is ALSO depressing, for opposite reasons. They also tend to be very cutesie/acronym prone--I quit reading after too many "got three nice embies!" and suchlike. But if you find one that you're comfortable on, more power to you--I just didn't like them.

Finally, blogwise you should check out the Stirrup Queens. The woman who runs that site has twins but is still very active in the infertility community (and trying to have another kid). She has links to every infertility blog out there, I think, and some of them are good to read.

We didn't buy any books, although our doctors kept recommeding "Conceptions and Misconceptions," presumably because they wrote it. Nat, maybe you have a comment here?

Expense--we shifted around insurance plans so that we would have one cycle totally covered, for which we are grateful. Certain states mandate IVF coverage--Resolve has the details.

If you have zero coverage, you are looking at $10K or more for an IVF cycle. Take some time to think about this, and whether it makes sense for you. Adoption is also quite expensive, but there is a tax credit of several $K to help.

Again, I'm sorry and I know this is an emotional and stressful time. Please feel free to ask more questions or to email me (address on main page).

chall said...

DJMH> Thanks for answering.

I'll cross fingers and hope all goes well!!

Anonymous said...

Thanks for the advice. Kissing ovaries are when the two ovaries are joined together behind the uterus. It makes it difficult for the egg to make it's way into the fallopian tubes. Yes it is quite a stressful and emotional time especially since 7 of my friends are either expecting or just gave birth.

Dr. Jekyll and Mrs. Hyde said...

Anon, yes, it always seems to be the case that one is diagnosed with fertility problems at the exact same time that every single person one knows has a baby. Three women in my lab alone got pregnant while we were trying--plus both sisters-in-law, my cousin...it's just wretched. It's completely normal to feel like you can't be happy for them. Don't beat yourself up. Please feel free to vent here. When you're ready, talking with your friends can help too.

scarabee said...

The perfect opportunity to abuse lab equipment for personal gain!

Congratulations on such a good harvest. :)